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2 Applications and challenges of smart responsive multifunctional nanoplatforms in bladder cancer diagnosis and treatment 2.1 Current status of bladder cancer treatment and the necessity of nanomedicine intervention 2.1.1 Standard treatment approaches for bladder cancer and their limitations Transurethral resection of bladder tumor (TURBT) serves as the primary surgical modality for early-stage bladder cancer, particularly non-muscle-invasive bladder cancer (NMIBC)